These types of vaccines are antigenic proteins that are genetically engineered into a consumable crop. The strategy is that the plant food product haves the protein witch is obtained from some disease causing pathogen. People eat the plant food, the food is digested, and some of the protein makes its way into the blood. You will find that edible vaccines also show some disadvantages ranging from long growth rates to creating toxins.
How to produce-
Antigens of several pathogens produce immunogenic response when delivered orally; such antigens are good candidates for edible vaccines. The mechanism, in simple terms, is as follows. The gene encoding the orally active antigenic protein is isolated from the pathogen, and a suitable construct for constitutive or tissue -specific expression of the gene is prepared. The gene construct is introduced and stably integrated into genome of selected plant species, and is expressed to produce the antigen. The appropriate plant parts having the antigen may be fed raw to animals or humans to bring about immunization. For animals, crops used as feed, e.g., alfalfa, and other forage/ fodder crops are suitable for the expression of such antigens, while for humans fruits like banana, which are consumed raw, have to be used.
The edible vaccines are produced from transgenic plants in witch orally active antigen of the target pathogen is expressed and accumulated, and witch is fed to animals/ humans for immunization against the pathogen.
- Transgenic Potatoes for Diarrhea
- Transgenic Tomatoes against Diarrhea
- Cost effective.
- Easy to store
- Acceptable for poor developing country.
- Not fear of contamination.
- Heat stable.
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